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Acknowledgements This work was supported by funding from the National Natural Science Foundation of China (No

On the other hand, lowering carbohydrate availability can enhance reliance on endogenous oxidative signals during exercise, amplifying p53 activation and subsequent mitochondrial gene expression, demonstrating how naturally occurring, transient H 2 O 2 pulses can be harnessed to potentiate adaptive remodeling [255]

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Our mitochondria also have specialised uncoupling proteins (e.g

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