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GLP-1 medications interact with certain drugs, supplements, and substances that may reduce efficacy or increase side effects

Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways

Learn more about the differences in GLP-1 medications, side effects, and which prescription treatment may be the right one for you.