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in people age 75 to 84, the annual incidence was 3.2% (32 of every 1,000 people)

Hangovers result when the after-effects of alcohol leave the body dehydrated and full of toxic byproducts
[DOI] [Google Scholar] 61.Endo H., Miyazaki K., Ose K., Imahori Y

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This makes constant region optimization a valuable complement to variable region humanization, particularly for antibodies intended for clinical use where precise control of immune activity is critical