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Several reviews discuss the potential benefits of NO and H 2 S availability in biological systems and the association of decreased levels with the development of cardiovascular diseases and an increased risk of pathogenic events [138,139,140]

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The nonenzymatic initial reaction between 1 M roGFP2 WT (S 2 ) and physiological millimolar GSH concentrations was too slow to be detectable and to be of any relevance in the presence of glutaredoxins in accordance with previous analyses 32