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4.3.3 HMGB1/5HT7R/Nrf2/xCT/GPX4 While HMGB1 functions as a DAMP and promotes inflammation, it has also been reported to promote ferroptosis via promoting hepcidin expression and secretion (which blocks iron efflux and increases intracellular iron level) and by suppressing the Nrf2/HO-1 axis (Davaanyam et al., 2023
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2 ) was also recently cited as a new protector against ROS damage
