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Furthermore, the autophagy receptor FUNDC1 has been shown to induce mitochondrial fragmentation, in addition to its involvement in the essential role of mitophagy (Yang et al., 2022), which subsequently results in ATP depletion and a significant decline in mitochondrial mass (Wang and Zhou, 2020)

61 demonstrated that NR supplementation altered the gut microbiome in mice and demonstrated that the gut microbiome change was able to impact weight gain in mice fed a high-fat diet

Their dependence on NAD+ has made them important targets for investigations of enzyme-cofactor interactions and NAD+-associated regulatory mechanisms

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