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Conversely, other satiety signals induced by gut-brain peptides such as GLP-1 [13-15], GLP-2 [40] and cholecystokinin produced a short-term effect, while insulin and leptin [41] inhibit the appetite by increasing the formation of pro-opiomelanocortin (POMC) and reducing NPY action

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Hamann S, Malmqvist L, Wegener M, Fard MA, Biousse V, Bursztyn L et al

So is the desire for maximum effectiveness