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Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis

One emerging therapeutic strategy involves inhibition of NADPH oxidase (NOX) enzymatic activity, with compounds such as ebselen, S17834, and GKT137831 showing potential across various disease models

Cardiac hypertrophy has been inversely correlated with the expression of miR-1 (Sayed et al., 2007) and miR-1 depleted mice show cardiac defects, including misregulation of cardiac morphogenesis, electric conduction, and cell proliferation (Yang et al., 2007

SOD is an important antioxidant enzyme that catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide, decreasing oxidative damage in lung tissues