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In addition, endothelial cell activation leads to increased production of reactive oxygen species (25) that can cause oxidative modification of apoB-containing lipoproteins (26)

Hence, the presence of metastasis should generally be considered as a contra-indication to surgical resection

Backes J, Anzalone D, Hilleman D, Catini J

The triglycerides are mixed with phospholipids and cholesterol, and surrounded with a protein coat

doi:10.1016/j.jbior.2012.09.008
