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Nuclear-localized PKM2 co-activates HIF1 the aerobic glycolysis regulator to reshape a metabolic landscape that favors glucose anabolic fate towards lipid biogenesis Our data so far revealed that in the absence of ATM, insulin-sensitive cells fail to translate the hormonal signal into an instantaneous metabolic transition that fosters anabolic reactions that are particularly important for general growth and development during early childhood to early puberty 84

J Clin Med 8(5):756 Darras VM, Van Herck SL, Heijlen M, De Groef B (2011) Thyroid hormone receptors in two model species for vertebrate embryonic development: chicken and zebrafish

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Thus, mTOR inhibition may represent a potential therapeutic strategy for mitigating manganese-induced neurodegeneration

TargetP2.0 (T) [46], LOCALIZER (L) [47] and PredAlgo (P) [48] predictions (Additional file 1 Table S1) indicate variable targeting of GSTL and GSTI isoforms to plastids (M, mitochondria