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A level of 80g/10 units a day Gastrointestinal disorders: coeliac or any disorder affecting the small bowel Pregnancy: preferential delivery of folate to foetus rather than mothers tissues, deficiency in utero increases the risk of neural tube defects Haematological disorders: increased red cell destruction (sickle cell anaemia, haemolytic anaemias) and those with abnormal haematopoiesis Exfoliative skin disorders (e.g