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Combination approaches that pair GSH depletion with ferroptosis induction, immunotherapy, or chemotherapy may help overcome resistance, while standardized manufacturing and rigorous toxicity evaluation will be critical for regulatory approval
In 2023, Omaveloxolone received FDA clearance for Friedreichs ataxia 171 , making it the first drug approved for any monogenic mitochondrial disease 172

10.1016/j.lungcan.2014.04.005 96 KimK

Mol Cancer (2019) 18:103
Rapid reduction of MDCK cell cholesterol by methyl--cyclodextrin alters steady state transepithelial electrical resistance
