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A 2017 review summarised neuroprotective properties of silymarin in animal models, including: Reduction of amyloidogenic activity (relevant in Alzheimer's research) Anti-inflammatory action in nerve tissue Reduction of oxidative stress in the brain Possible positive effects on cognitive function Possible reduction of stroke risk Whether these effects can be achieved in humans at attainable concentrations of silymarin in particular whether sufficient quantities can cross the blood-brain barrier remains unclear

It has been demonstrated that ALA is able to protect hippocampal neurons in primary culture from both A peptides and Fe/H 2 O 2 mediated toxicity and that its metal chelating properties may increase the extraction of A peptides from cortical areas [124]

Tan Q, Niu K, Zhu Y, Chen Z, Li Y, Li M, et al

Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity

[PMC free article] [PubMed] [Google Scholar] 42.Effect of N-acetylcysteine on metabolic profile in metabolic syndrome patients