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Further research has shown that vitamin C can also increase collagen gene expression in fibroblasts [31,32,33,34,35]
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NRF2-mediates HO-1 expression and ferroptosis resistance in KRAS mutant colorectal cancer cells, whereas combined cetuximab with RSL3 increases KEAP1 expression leading to inhibition of NRF2/HO-1 pathway [35]
A dual role of Heme Oxygenase-1 in Cancer cells
