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For example, an APOE 4 carrierwhose allele is consistently linked to higher LDL-C and coronary heart disease riskwho also carries the GLP1R rs6923761 A allele, which attenuates GLP-1-mediated glycaemic response, may warrant closer lipid monitoring and earlier adjunctive lipid-lowering therapy when treated with tirzepatide [106,107]

3.1.2 Exenatide As the first GLP-1R agonist approved for T2DM, EX is a new class of compound and a synthetic product of exendin-4, which is a compound naturally derived from the Gila monster and has multiple hypoglycemic mechanisms: inhibiting of glucagon release from cells, slowing of gastric emptying, decreasing appetite and increasing glucose-dependent insulin secretion (46, 47)

Egypt J Hospital Med 88(1):34263432

GLP-1 (glucagon-like peptide-1) has quickly become one of the most talked-about hormones in metabolic healthand for good reason

What confuses people is that two listings tied to the same drug name can still produce very different final bills