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The precise mechanism through which HMGB1 induces EMT in asthma remains unclear, but it may potentially involve RAGE and the phosphatidylinositol 3 -kinase/Akt/glycogen synthase kinase 3/-catenin (PI3K/Akt/GSK3/-catenin) signaling pathway (92) or the RAGE/NF-B signaling pathway (93)

This process consumes cellular methyl donors and, critically, prevents nicotinamide from being recycled into NAD+

Oswald, L

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Neuroprotection of developing brain There is an urgent need for therapies that can improve outcome after neonatal and pediatric brain injury as current therapies are only partially effective [134, 135, 169172]