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There is no substance-use or alcohol-use screen

In males with PWS, premature pubarche is associated with early pubic hair growth, elevated levels of serum dehydroepiandrosterone sulfate or serum dehydroepiandrosterone, and advanced bone age
Weight gain is a major risk factor of developing IIH

Women of childbearing potential should discuss contraception, as tirzepatide can decrease exposure to oral contraceptives, requiring backup contraception for 4 weeks after initiation and after each dose increase

1 Lean muscle mass naturally diminishes with age