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256 In addition, the dipeptidyl peptidase IV (DPPIV) inhibitor vildagliptin inhibits intestinal epithelial apoptosis by suppressing the PI3K/AKT/NF-B pathway

274,275 Therapeutic strategies targeting oxidative stress and mitochondrial dysfunction include using antioxidants like alpha-lipoic acid (ALA), which improves neuropathic symptoms and nerve conduction velocities in patients with DPN