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Two 50-year-old executives with identical calendars can have opposite responses to the same intervention because their baseline biology differs catecholamine tone, BDNF expression, mitochondrial function, sleep architecture, and inflammatory load

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Further research is likely to identify novel therapeutic agents, to use singly or in combination with anti-fibrotic agents, to improve clinical outcomes

However, approximately half of the eggs become trapped in the tissues and attract inflammatory cells, leading to the formation of granulomas and fibrosis

It has recently been proposed that the mediator engages in transcription via phase separation 62,63 , prompting us to investigate its potential involvement in mitotic chromosome organization via phase separation