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doi:10.1093/jn/124.suppl_1.124S

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

Tumor-induced glutamine competition promotes glutamate secretion to modulate immune responses Cancer cells strengthen their resistance to tumor-infiltrating lymphocytes (TILs) partly through the metabolites released into the TME, contributing to its hostility

doi: 10.1016/j.tem.2004.05.011

Using genomics, the authors identified the missing thiamine biosynthesis protein 13 (THI13) gene and engineered a strain capable of de novo thiamine biosynthesis, which yielded a significant although moderate increase in lipogenesis (~4% vs