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We explored differentially expressed genes in our mutant strains within these pathways to determine if the observed phenotypic growth differences could be explained at this level of regulation

Activated AMPK signaling regulates protein and lipid synthesis by inhibiting mTORC1 through activation of tuberous sclerosis complex 2 (TSC2) and phosphorylation of raptor (234237)

tant donn que ces substances sont prsentes dans les cellules, elles sont parfaitement places pour servir de premire ligne de dfense contre les dommages oxydatifs, qui sont considrs comme la ligne de dfense la plus efficace de tous les mcanismes sur lesquels notre corps s'appuie pour contrer les effets des radicaux libres

Hum Mol Genet 6(11):19251931 Sleat DE, Wiseman JA, El-Banna M, Price SM, Verot L, Shen MM, Tint GS, Vanier MT, Walkley SU, Lobel P (2004) Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

Am J Physiol Regul Integr Comp Physiol 2014;307:R1207R1215