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10.1517/14656566.4.11.1967 111 LuoJ.YangC.LuoX.YangY.LiJ.SongB.et al (2020)

The endothelial glycocalyx and vascular permeability The physical architecture of the vasculature functions as a conduit to deliver oxygenated blood to meet the metabolic demands of the bodys tissues

Proc Natl Acad Sci USA 104(9):32193224 Harrington LS et al (2008) Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells

It exerts neuroprotective and antioxidant effects and delays disease progression by limiting the extent of lipid peroxidation and cell membrane damage from oxidative stress [178]

The immune cells in these patients are dealing with such an extreme, unrelenting burden of oxidative stress and mitochondrial lipid damage that they have frantically ramped up their own internal glutathione production in a desperate attempt to survive