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Methods Based on a systematic literature review (SLR) and Bayesian network meta-analysis (NMA), the efficacy and safety of semaglutide 2.4 mg, liraglutide 3 mg and tirzepatide 5, 10 and 15 mg were compared in adults without type 2 diabetes, and with either obesity (body mass index [BMI]30 kg/m2) or overweight (BMI27 kg/m2) with 1 obesity-related complication

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A Cox proportional hazard model was used to assess the cardiorenal protective effects between the GLP-1RA and DDP-4i groups

Structured resistance training (24/week) Adequate protein intake (1.21.6 g/kg/day) Micronutrient optimization (Vitamin D, B12, Omega-3) Avoiding extreme caloric restriction Theres also growing scientific interest in myostatin inhibitors such as Bimagrumab which have shown the ability to preserve lean mass and enhance fat loss when combined with GLP-1 therapies

Tirzepatide is an FDA-approved injectable medication designed to help with weight management and the treatment of type 2 diabetes