history of glp-1 drugs Historical timeline biology, receptor agonist discovery, and Upgrading from Overweight: The Effects

Known Vision-Related Risks Associated with GLP-1 Drugs Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) One of the most serious vision-related side effects linked to Ozempic, Wegovy, and similar GLP-1 drugs is NAION, a condition sometimes referred to as an eye stroke. NAION occurs when there is a sudden decrease or blockage of blood flow to the optic nerve, resulting in damage that prevents visual signals from reaching the brain

Importantly, individuals with T2DM continue to benefit from GLP- 1's glucose-lowering effects

5 This is in contrast to the typical call for most accidental overdoses involving children

Intestinal and brain cells contain prohormone convertase 1 (PC1), which is able to cleave proglucagon into Glicentin, Oxyntomodulin, GLP-1, GLP-2 and IP-2, while pancreatic islet cells contain prohormone convertase 2 (PC2), which capable of cleaving proglucagon into Glucagon and MPGF

Mostly, these side effects were mild and dose-dependent