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Two hormones released by enteroendocrine cells in the gut mucosa were subsequently discovered to be largely responsible for the incretin phenomenon

Earlier research and case reports also suggest a significant rise in NAION cases among patients treated with semaglutide and tirzepatide, with some reports indicating up to a fourfold increase in risk

By restricting calcium entry and blocking specific intracellular signaling pathways, SCFAs physically calm the mast cell and drastically reduce the production of pro-inflammatory cytokines like Tumor Necrosis Factor (TNF)

doi: 10.1016/j.clinph.2021.05.033 60 LinDSYuALLoHYLienCWLeeJKChenWJ

Thus, Kim et al