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While PEGylation and lipidation can extend systemic circulation, they also risk triggering complement activation, accelerated blood clearance (ABC), and immunogenicity
Full agonism of these GPCRs through both G-protein and -arrestin signaling arms may be suboptimal, promoting undesirable off-target effects and receptor desensitization
doi: 10.1530/JOE-13-0525
According to NICE Clinical Knowledge Summary (CKS) on PCOS, lifestyle modification with weight management is a first-line intervention for overweight women with PCOS
"Stop comparing ur life 2any1 else's," she tweeted the day before
