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For those who do choose to drink, our guide to the best alcohol options on tirzepatide identifies lower-risk choices

| Take home message According to data from two randomised controlled trials (STEP 1 and SUSTAIN 8), up to 40% of the weight lost on semaglutide (Wegovy/Ozempic) may be from lean mass

It works by enhancing insulin secretion in response to meals, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways

Management Flow Chart Emerging registry and cohort data suggest GLP-1 RAs are not associated with increased risk of major congenital malformations compared to insulin