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Both medications carry a boxed warning related to thyroid C-cell tumors observed in animal studies, which is why a personal or family history of medullary thyroid carcinoma or MEN2 syndrome is a contraindication for both
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Moreover, insulin resistance impairs glucose uptake and utilization, further disrupting the hearts energy metabolism (53)

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When your blood sugar drops too low (a condition known as hypoglycemia), your body responds by trying to raise it

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