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Fourthly, the differential market availability of tirzepatide across various countries, with some regions yet to introduce the drug, may introduce additional biases into the analysis

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The most common adverse events were usually short-lived gastrointestinal-related events, which were generally mild to moderate in nature, including nausea, diarrhoea, decreased appetite and vomiting

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After being produced by enteroglucagon-producing L cells in the lower gut in response to food intake, incretins travel to various receptors including the pancreas and cause glucose-dependent insulin release causing lowering of elevated blood glucose [1]