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Although the exact mechanism to explain reduced insulin concentrations after IGF-1 infusion is not well understood, our lab has previously shown that infusion of LR3 IGF-1 attenuates glucose stimulated insulin secretion in vivo and islet cell secretion of insulin in vitro (White et al., 2021)

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A range of nonvalidated complementary tests have also been proposed by several authors with the aim of obtaining a marker to confirm the diagnosis [97]

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