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NICE Technology Appraisal (TA875) recommends semaglutide (Wegovy) only for adults with at least one weight-related comorbidity and a BMI 35 kg/m (or 32.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean backgrounds)

[3] For weight management: If discontinuing tirzepatide prescribed for obesity, consider: Establishing a structured nutrition and exercise program before stopping Transitioning to alternative weight management medications if appropriate Setting realistic expectations about weight regain Implementing behavioral strategies and support systems Regular weight monitoring and early intervention if significant regain occurs Practical discontinuation steps: If cost or access issues are driving discontinuation, discuss these openly with your healthcare team, as patient assistance programs, alternative formulations, or therapeutic substitutes may be available

Clin Med

Metabolic: Euglycemic DKA The risk of euglycemic DKA is very uncommon, but its a clinically important and real complication to be aware of in patients using GLP-1 agonists

Presentaciones de aGLP-1 de administracin diaria Se debe instruir al paciente sobre las nuevas posologas y condiciones de administracin de estos aGLP-1 (ver tablas anteriores) La semaglutida oral tiene unas condiciones de administracin exigentes que debe conocer el paciente