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Beyond its ability to increase the intracellular pool of Ca 2+ , GLP-1 also affects insulin secretion via cAMP-mediated regulation of exocytosis (Figure 6)

While DPP-4 expression is significantly increased in patients with obesity and T2DM, the incretin effect is markedly impaired

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Hematologic Megaloblastic anemia: pallor, fatigue, weakness Glossitis (beefy red tongue) Jaundice (mild, due to ineffective erythropoiesis) Pancytopenia (in severe cases) 2