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Semaglutide works by enhancing insulin secretion in response to meals, reducing glucagon release, and slowing gastric emptying, which helps lower blood sugar levels and promotes a sense of fullness

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Introduction Once-weekly subcutaneous semaglutide, 2.4 mg, a glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA), is available for weight management in people with obesity (or overweight and 1 weight-related comorbidities)

Pathophysiology: As detailed above, thiamine deficiency causes an increase in anaerobic metabolism, increased oxygen demand and systemic vasodilation through increased adenosine levels