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The relatively high subcutaneous bioavailability (approximately 6275%) suggests efficient absorption from the subcutaneous depot
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Personal or family history of medullary thyroid carcinoma, MEN 2 syndrome, pregnancy, breastfeeding, or active pancreatitis are absolute contraindications regardless of dose
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Notably, tirzepatide 5 mg produced greater weight loss than semaglutide 1 mg in this trial, which may contribute to blood pressure differences
