research retatrutide Retatrutide Peptide: Triple Agonist Mechanism,

the data sits at the ingredient-level human evidence tier

Endocrinology 153:57705781 Wei R, Ma S, Wang C, Ke J, Yang J, Li W, Liu Y, Hou W, Feng X, Wang G, Hong T (2016) Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner

The FDA has approved Semaglutide GLP-1 injections for long-term use for weight loss

19,20 The mechanisms of SGLT2 inhibitors are multifactorial and related to a diuretic effect, improved myocardial and vascular metabolism leading to lower preload, reduced afterload, and improvements in cardiac structure and function

Thats not where the risk-benefit lies. Given that health insurance wont cover GLP-1s if you arent obese, dont have type 2 diabetes, or arent overweight with cardiovascular disease, the cost can add up for years before you know whether the spend was really worth it