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Similar findings were reported when administering GLP-1RAs with drugs from BCS class II (low solubility, high permeability) such as statins[44], tacrolimus[45] and other medications from class III (high solubility, low permeability) such as angiotensin-converting enzyme inhibitors[46] as no significant changes in C max , t max , and area under the curve were reported
The result showed that the protein expressions of PI3K, P-Akt and m-TOR were highest in group 3, lowest in groups 1 and 2, and significantly increased in group 4 than in group 5, but they did not differ between groups 1 and 2 (Fig
