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Semaglutide works by mimicking a natural hormone (GLP-1) that regulates blood sugar and helps control appetite

Abbreviations: Ex4: exendin 4, CPP: conditioned place preference, DA: dopamine, PR: progressive ratio, VTA: ventral tegmental area, NAc: nucleus accumbens, NTS: nucleus of the solitary tract, LDTg: laterodorsal tegmental nucleus, CeA: central amygdala, EPM: elevated plus maze, SA: self-administration, KO : knockout, WT: wild type, FR: fixed ratio, HFD: high-fat diet, OX1R: orexin-1 receptor, ArcN: arcuate nucleus, PVN: paraventricular nucleus, BLA: basolateral amygdala, DMHipp: dorsomedial hippocampus

This remains theoretical until phase 3 data is published

a Four drug conditions: placebo, oral cannabis, smoked cannabis, and vaporized cannabis

Age matters too