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The STEP-HFpEF trial was a randomized, double-blind, placebo-controlled trial that analysed the effects of weekly subcutaneous semaglutide in patients with obesity-related HFpEF

All studies reported post-cessation weight data in overweight and obese populations, with some focussing on comorbidities such as type 2 diabetes

However, clinical trial rates of anxiety remain low (below 5%), so coincidental anxiety or anxiety triggered by rapid lifestyle change is also common

If you are on a high dose of tirzepatide, your healthcare provider will usually start semaglutide at a lower dose (0.25 mg) to help your body adjust and reduce the risk of side effects

Its important to talk to your doctor about managing constipation, especially if its an ongoing problem