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The first of these trials, the STEP 1 trial, compared 2.4 mg of weekly semaglutide plus lifestyle intervention with placebo plus lifestyle intervention for 68 weeks in obese nondiabetic patients, and the result showed a clinically significant and sustained average weight loss among the semaglutide group (14.9%) and a difference of 12.4% compared to the placebo and lifestyle group (2.4% mean weight loss) [29]