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Extra-pancreatic effects of incretin-based therapies: potential benefit for cardiovascular-risk management in type 2 diabetes

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Hypoglycaemia: Risk is low when used alone but increases if combined with insulin or sulfonylureas (for example, gliclazide or glibenclamide)

On the flip side, some people need to take more Calocurb to reach that sweet spot where they feel full enough to cut back on eating and achieve weight loss

Other important side effects and warnings include: Injection site reactions such as redness or itching Increased heart rate Hypoglycemia (uncommon with semaglutide alone but more likely when combined with insulin or sulfonylureas