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Berberine also has meaningful effects on lipids (LDL and triglyceride reduction) and some evidence for gut microbiome modulation

1 Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB

Persistent mouth sores lasting over three weeks require urgent GP referral to exclude serious pathology including oral cancer per NICE guidance

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