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Habener, Jens Juul Holst Historical timeline depicting seminal events in the discovery and development of glucagon-like peptide therapeutics.

doi: 10.1016/j.lfs.2020.118174 102 HadidiMKarimabadiKGhanbariERezakhaniLKhazaeiM
Unlike DPP4, which is found on the cell surface, DPP8 and DPP9 are cytosolic enzymes that are widely distributed and conserved across different species [62, 63]

Novo Nordisk and Eli Lilly continue to dominate., Although Pfizer discontinued its in-house oral GLP-1 candidate danuglipron in April 2025 following a liver-injury signal, it has doubled back into obesity and GLP-1 with its multi-billion-dollar acquisition of Metsera

[DOI] [PMC free article] [PubMed] [Google Scholar] [18].Moran LJ, Noakes M, Clifton P, et al
