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As expected, the three best compounds in vivo, 14 , 22 and 23 , had all (1) improved stability in NEP 24.11 degradation assays, (2) prolonged half-lives in mouse plasma and (3) decent potency

cAMP accumulation in pancreatic beta cells The accumulation of cAMP was measured in cultured BRIN-BD11 at different time points upon agonist treatment

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