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doi: 10.1210/endo.135.2.8033807

Major GLP-1 Weight-Loss Drugs and Their Makers Ozempic (semaglutide): Novo Nordisk, originally for diabetes, widely used off-label for weight loss

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To further investigate why these three missense mutations led to a significantly increased GLP-1R ECD affinity of semaglutide mutant 524, a comprehensive structural biophysical analysis [50] was conducted for the 10000 structural models built by Modeller [44] with a structural electrostatic perspective
